Risk factors for permanent stoma following sphincter-preserving anterior resection in rectal cancer: A retrospective multicenter observational study

Background Sphincter-sparing rectal cancer surgery seeks to avoid terminal stomas, yet they remain common. To identify patients who may benefit from an upfront terminal ostomy, we aimed to determine preoperative risk factors and develop a risk calculator. Methods This multicenter observational retrospective cohort study included consecutive patients undergoing sphincter-sparing anterior resection for rectal cancer between January 2016 and January 2020 at 6 tertiary hospitals. The stoma-free status was analyzed 2 years after surgery. Results We included 639 patients: 373 with primary stoma (58.4%) and 29 with secondary stoma (4.5%). Two years after surgery, 76 (11.9%) patients had permanent stoma. Patients with anastomotic leakage showed a lower rate of stoma closure 2 years after surgery (No 86.3% vs Yes 69.4%; P = .002). The main causes for non-primary stoma reversal were disease progression (52.4%) and patient decision (19.0%). Preoperative factors independently associated with permanent stoma 2 years after surgery were male sex ( P = .016; OR = 2.16), tumor height ( P = .001; OR = 0.88), synchronous liver metastases ( P = .025; OR = 2.71) and lung metastases ( P = .001: OR = 7.05). Conclusions Preoperative risk factors associated with permanent stoma in patients undergoing anterior rectal resection include sex, tumor height, and synchronous liver or lung metastases. Surgeons should consider preoperative factors associated with the risk of permanent stoma and inform patients about the potential need for a permanent stoma.