Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 2013Cellular Physiology and BiochemistryOpen Access

Acute Kidney Injury Reduces Phagocytic and Microbicidal Capacities of Alveolar Macrophages

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does renal ischaemia-reperfusion injury alter the phagocytic and microbicidal capacities of alveolar macrophages in rats with lung inflammation?

Population

Rats sensitised to OVA (lung inflammation model)

Comparison

60 min of renal ischaemia-reperfusion injury (IRI) vs Control animals

Design

Preclinical

Follow-up

24 hours after antigen challenge

Authors

RSReinaldo C. SilvaUniversidade de São PauloMLMaristella Almeida LandgrafUniversidade PaulistaMCMatheus Corrêa-CostaBeth Israel Deaconess Medical Center

Discussion

Loading...

Member takes

Implication

Renal IRI may impair alveolar macrophage defense in inflamed lungs; hypothesis-generating for remote effects on pulmonary immunity, needs human validation.

Structured PICO

Does renal ischaemia-reperfusion injury alter the phagocytic and microbicidal capacities of alveolar macrophages in rats with lung inflammation?

P
Population
Rats sensitised to OVA (lung inflammation model)
I
Intervention
60 min of renal ischaemia-reperfusion injury (IRI)
C
Comparator
Control animals (immunised and challenged with OVA but without prior submission to renal ischaemia)
O
Outcome
Phagocytic and microbicidal capacity (bacterial killing of Klebsiella pneumoniae) of alveolar macrophages 24h after antigen challengesurrogate

Renal ischaemia-reperfusion injury reduces the phagocytic and microbicidal capacity of alveolar macrophages, thereby altering lung inflammation in response to OVA.

Cite This Study

Silva et al. (2013) studied this question.

synapsesocial.com/papers/6a71504cb5c1fe5ca9dfd2bchttps://doi.org/10.1159/000343359
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The relationship of inoculum size to lung bacterial clearance and phagocytic cell response in mice.1979 · 125 citations
  2. 2Acute kidney injury in an infectious disease intensive care unit - an assessment of prognostic factors2008 · 41 citations
  3. 3Allergen-specific Th1 cells fail to counterbalance Th2 cell–induced airway hyperreactivity but cause severe airway inflammation1999 · 635 citations
  4. 4Clearance of surfactant lipids by neutrophils and macrophages isolated from the acutely inflamed lung2002 · 34 citations
  5. 5Protective Role of Macrophages in Noninflammatory Lung Injury Caused by Selective Ablation of Alveolar Epithelial Type II Cells2007 · 70 citations