Metabolic regulation of aged hematopoietic stem cells: key players and mechanisms

Aging is accompanied by a gradual decline in the function and regenerative capacity of hematopoietic stem cells (HSCs), which leads to increased susceptibility to blood disorders. Recent studies have highlighted the critical role of metabolic regulation in governing the fate and function of HSCs, and alterations in metabolism play a critical role in the age-related changes observed in HSCs. Metabolic processes, including glycolysis, mitochondrial function, nutrient sensing, and inflammation, profoundly influence the maintenance, self-renewal, and differentiation potential of the HSC pool.