Core‐Structure‐Oriented Asymmetric Organocatalytic Substitution of 3‐Hydroxyoxindoles: Application in the Enantioselective Total Synthesis of (+)‐Folicanthine

Something constructive: The title reaction involving 3-hydroxyoxindoles gives 3,3′-disubstituted oxindoles with concomitant generation of an all-carbon quaternary stereogenic center in high yield and excellent enantioselectivity. This reaction enabled the enantioselective construction of hexahydropyrroloindole skeletons and the first catalytic enantioselective total synthesis of (+)-folicanthine.