Why the study?
The roles of immune-inhibitory receptors PirB and its human orthologue LILRB2 in nonalcoholic steatohepatitis pathogenesis were unknown.
Population
NASH mice, PirB -/- bone marrow chimaeras, and human peripheral blood monocytes
Comparison
Knockout of ANGPTL8, PirB deficiency, or PirB ectodomain protein vs controls
Design
Preclinical animal and cellular experimental study
Authors
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LILRB2 blockade may limit macrophage-driven NASH fibrosis; novel mechanism leaves therapeutic translation open pending clinical studies.
PirB/LILRB2-ANGPTL8 signaling mediates macrophage recruitment in NASH fibrogenesis, presenting a potential therapeutic target.
Chen et al. (2022) studied this question.
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