The diuretic and natriuretic effects of ANF are exerted at distinct sites, with only natriuresis being related to an increase of extracellular cGMP, supporting the heterogeneity of the ANF effector system.
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ANF diuresis dissociated from natriuresis in animals; leaves open distinct human therapeutic targeting pending confirmatory studies.
Willenbrock et al. (1989) studied this question.
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