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January 30, 2006Journal of Cardiovascular Electrophysiology

Intraventricular conduction anomalies were identified in 59 of 78 gene carriers, with PR and QRS duration being longer than in non-carriers and progressively aggravating with aging, leading to pacemaker implantation in 5 cases.

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Population

78 patients carrying a SCN5A mutation linked to Brugada syndrome from 16 families.

Design

Cohort

Authors

VPVincent ProbstMAMarie AllouisFSFrédéric Sacher

Discussion

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Overview

May support serial ECG monitoring in SCN5A carriers; extends conduction phenotype data yet remains hypothesis-generating.

Structured PICO

P
Population
78 patients carrying a SCN5A mutation linked to Brugada syndrome from 16 families (inclusion required a SCN5A mutation identified in a BS proband and at least two family members as mutation carriers).
C
Comparator
Relatives carrying no mutation
O
Outcome
Cardiac conduction defect and its evolution with aging (including PR and QRS duration, and intraventricular conduction anomalies)surrogate

The prevailing phenotype in carriers of a Brugada syndrome SCN5A mutation is progressive cardiac conduction defects, highlighting the need for long-term clinical and ECG follow-up.

Cite This Study

Probst et al. (2006) studied this question.

synapsesocial.com/papers/6a71551726a7f98052ddb44dhttps://doi.org/10.1111/j.1540-8167.2006.00349.x
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