Why the study?
Does the change in 86Rb uptake by erythrocytes correlate better with therapeutic response than plasma digoxin concentrations in patients treated with digoxin for atrial fibrillation?
Does the change in 86Rb uptake by erythrocytes correlate better with therapeutic response than plasma digoxin concentrations in patients treated with digoxin for atrial fibrillation?
An in vitro assay measuring 86Rb uptake by erythrocytes may provide a better indicator of therapeutic response to digoxin than standard plasma digoxin concentrations.
Erythrocyte 86Rb uptake may better reflect digoxin response in AF than plasma levels; leaves open prospective validation before practice change.
1 An in vitro technique is described for measuring the uptake of 86Rb by human erythrocytes. 2 Fifteen patients were treated with digoxin for atrial fibrillation and other fast arrhythmias. 3 86Rb uptake by the patients' own red cells fell from pre-treatment values during digitalization. 4 The therapeutic response of patients with atrial fibrillation correlated better with the changes in 86Rb uptake than with plasma digoxin concentrations.
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Aronson et al. (1977) studied this question.
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