Ewing sarcoma of the rib can rarely present as superior vena cava syndrome in young adults.
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Broadens SVC syndrome differential in adolescents; leaves open whether rib-origin Ewing sarcoma is underrecognized.
Ewing sarcoma is a malignant tumor of young adults comprising about 10%-15% of all bone sarcomas. Commonly, the long bones are affected but it can also originate from the rib, pelvis and spine. We present a large Ewing sarcoma in a 16-year-male, arising from the first right rib and manifesting with superior vena cava syndrome.
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Garnaik et al. (2025) studied this question.
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