Why the study?
Does protamine administration cause acute stent thrombosis in patients with drug-eluting stents?
Does protamine administration cause acute stent thrombosis in patients with drug-eluting stents?
Protamine administration following drug-eluting stent implantation may precipitate acute stent thrombosis, warranting caution.
Warrants caution with protamine after DES; leaves open any causal link or practice change.
The treatment of hemorrhagic complications of percutaneous interventions with protamine is an accepted practice. Concerns exist about the increased thrombo-genicity of drug-eluting stents. We report two cases of acute stent thrombosis following drug-eluting stent implantation related to protamine administration.
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Cosgrave et al. (2008) studied this question.
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