Congenital Deficiency of Fibrin-Stabilizing Factor

SINCE the discovery by Laki and Lorand1 of a plasma factor responsible for rendering a fibrin clot insoluble in 5-M urea and in 1 per cent monochloracetic acid in the presence of ionized calcium, the importance of Laki-Lorand factor,2 also called fibrinase3 or fibrin-stabilizing factor (F.S.F.),4 has been recognized in the physiology of blood coagulation. The first researchers in this field concentrated on the identification,2 purification,5 , 6 measure of activity7 and mechanism of action of this factor,8 but at that time, its clinical implications were still unknown.Since 1960, when Duckert et al.9 first observed a familial hemorrhagic disorder by congenital . . .