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July 31, 2012AgingOpen Access

Tumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression?

Mikhail V. Blagosklonny

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Abstract

I discuss a very obscure activity of p53, namely suppression of senescence (gerosuppression), which is also manifested as anti-hypertrophic, anti-hypermetabolic, anti-inflammatory and anti-secretory effects of p53. But can gerossuppression suppress tumors?

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Cite This Study

Mikhail V. Blagosklonny (2012) studied this question.

synapsesocial.com/papers/6a715850ce524a4339c4e780 https://doi.org/10.18632/aging.100475

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathwayOriginal Research · 2010 · 278 citations
2Weak p53 permits senescence during cell cycle arrestOriginal Research · 2010 · 133 citations
3Cell cycle arrest is not senescenceOriginal Research · 2011 · 216 citations
4Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven agingOriginal Research · 2012 · 250 citations
5Growth stimulation leads to cellular senescence when the cell cycle is blockedOriginal Research · 2008 · 377 citations

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