Ivabradine may be an effective treatment option for inappropriate sinus tachycardia in renal transplant recipients who are intolerant to or fail beta-blocker therapy.
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May support ivabradine in beta-blocker-intolerant cases; leaves open confirmation by prospective trials in renal transplant recipients.
Inappropriate sinus tachycardia (IST) is a syndrome characterized by unexplained tachycardia (heart rate > 100 beats /min) and related symptoms at rest. We describe a case of a 35 year old male with end stage renal disease who developed IST after renal transplant in the surgical intensive care unit. Management of IST is usually nonspecific and includes bradycardic agents, radiofrequency ablation or surgical ablation of the sinus node. This patient was well managed with ivabradine (If pacemaker current inhibitor) after failure and intolerance of β-adrenergic blockers.
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Goyal et al. (2014) studied this question.
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