Why the study?
Does porous PLLA coating on glucose sensors improve angiogenesis and sensor performance compared to bare sensors in a rodent model?
Population
Rodent dorsum optical window model
Comparison
Porous poly-L-lactic acid coated glucose sensors vs Bare (unmodified, smooth surface) glucose sensors
Design
Preclinical
Follow-up
14 days
Authors
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Porous coatings merit testing in chronic fully implanted models; hypothesis-generating in rodents and should not yet change clinical sensor practice.
Does porous PLLA coating on glucose sensors improve angiogenesis and sensor performance compared to bare sensors in a rodent model?
Porous PLLA coating increases angiogenesis for fully implanted glucose sensors but does not improve percutaneous sensor performance or prevent current attenuation over 14 days.
Koschwanez et al. (2009) studied this question.
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