The incorporation of [Me-14C]choline into the phosphatidylcholine of subcellular fractions of rat liver has been examined. The mitochondrial fraction shows a minimal phosphatidylcholine synthesis compared with that produced by adding microsomes providing an incubation medium which allows adequate phospholipid synthesis is used. The small mitochondrial incorporation can be partly if not wholly explained by microsomal contamination or a non-energy dependent exchange process. It is concluded that the appreciable turnover of mitochondrial phosphatidylcholine observed in vivo can be explained most satisfactorily by assuming a transfer of newly synthesized phospholipid molecules from the endoplasmic reticulum.
No takes yet. Share an insight, caveat, or question.
Jungalwala et al. (1970) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: