Generation and Reaction of Carbamoyl Anions in Flow: Applications in the Three‐Component Synthesis of Functionalized α‐Ketoamides

Using a flow microreactor system, carbamoyllithium compounds were successfully generated and used for reactions with electrophiles to give various amides, including α‐ketoamides. The present method could be applied to the three‐component synthesis of functionalized α‐ketoamides using a carbamoyllithium compound, methyl chloroformate, and a functionalized organolithium reagent.