Oxidative stress and obstetric complications in pregnant women with inherited thrombophilia with and without low molecular weight heparin therapy

Introduction: Inherited thrombophilia (IT) presents genetic conditions associated with the risk of deep vascular thrombosis (DVT) and obstetric complications (OC) such as preeclampsia (PE), fetal growth restriction (FGR), stillbirth and placental abruption (PA). The aim of our study was to evaluate the frequency of OC and oxidative stress (OS) in women with IT during pregnancies with and without low molecular weight therapy (LMWH), compared to women with healthy pregnancies. Material and methods: We evaluated 60 pregnant women with IT diagnosed before ongoing pregnancy based on previous DVT or OC (study group) and 60 healthy pregnant women (control group). Blood samples were collected before delivery, along with placental tissue from all subjects, to determine the activity of CAT, GPX, GH, SH, GR, CuZnSOD, and MnSOD enzymes. Results: After the introduction of LMWH therapy, the total number of OC decreased significantly in women with IT. Analyzing the association between OC and different kinds of IT, we found significant association only between Factor V Leiden mutation and Protein C deficiency with GH/PE. Levels of SH are higher in IT; CAT, GPH and GR are three times more active in patients with IT with LMWH therapy compared to control group. Conclusion: Values of OS parameters in pregnant women with IT during delivery may confirm increased OS in those patients indicating that introduction of antioxidant therapy may be advisable.