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Genetic association study shows that variants tied to cardiorespiratory fitness influence diabetes, endocarditis, and creatinine, highlighting common biological pathways.
To our knowledge, this is the first genetic association study exploring how genes linked to cardiorespiratory fitness (CRF) relate to disease risk. By investigating shared genetics, we found indications that genetic variants linked to directly measured CRF also affect the level of blood creatinine, risk of diabetes, and endocarditis. Less certain findings showed that genetic variants of high CRF might cause lower body mass index, healthier HDL cholesterol, and lower resting heart rate.
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Nordeidet et al. (2023) studied this question.
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