What question did this study set out to answer?

To study the embryology of intercalated discs in rabbit cardiac muscle using electron microscopy.

March 25, 1957The Journal of Cell BiologyOpen Access

An Electron Microscope Study of the Embryology of the Intercalated Disc in the Heart of the Rabbit

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Population

Prenatal and postnatal cardiac muscle from rabbits (from 9.5 days after coitus to adult state)

Design

Preclinical

Authors

AMAlan R. MuirUniversity of Edinburgh

Discussion

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Implication

Affirms cellular organization of myocardium from embryogenesis in rabbits; leaves open translation to human development or repair.

Key Points

To study the embryology of intercalated discs in rabbit cardiac muscle using electron microscopy.
Analyzed prenatal and postnatal rabbit cardiac muscle using electron microscopy after osmium fixation and methacrylate embedding.
Examined muscle cells at various stages, starting from 9.5 days post-coitus to adult stage.
Identified that embryonic muscle cells are mononucleated while adult muscle cells may be multinucleated.
Observed that intercalated discs interrupt the myofilaments wherever a myofibrillar axis crosses a cellular boundary at all developmental stages.
Noted that intercalated discs increase in size and complexity as the heart develops, becoming identifiable by light microscopy.

Structured PICO

Population

Prenatal and postnatal cardiac muscle from rabbits (from 9.5 days after coitus to adult state)

Intervention

Electron microscopy after osmium fixation and methacrylate embedding

Outcome

Embryology and development of the intercalated disc

The study demonstrates that cardiac muscle is divided into cellular units by cell membranes from early embryonic stages to adulthood, with intercalated discs interrupting myofilaments at cellular boundaries.

Cite This Study

Alan R. Muir (1957) studied this question.

synapsesocial.com/papers/6a71628fa528af2d65c40c94 https://doi.org/10.1083/jcb.3.2.193

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An Electron Microscope Study of the Embryology of the Intercalated Disc in the Heart of the Rabbit

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

An Electron Microscope Study of the Embryology of the Intercalated Disc in the Heart of the Rabbit

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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