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August 4, 2026The American Journal of CardiologyOpen Access

Significance of Coronary Artery Calcium Found on Non–Electrocardiogram-Gated Computed Tomography During Preoperative Evaluation for Liver Transplant

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Key result

Non-gated CT calcium scoring excludes obstructive CAD, potentially avoiding angiography in ~26% of liver transplant candidates.

  • n=54

Why the study?

Does coronary artery calcium scoring from non-ECG-gated chest CT accurately rule out obstructive coronary artery disease in patients undergoing preoperative evaluation for liver transplant?

Population

54 patients undergoing preoperative evaluation for orthotopic liver transplantation who had a non-ECG-gated…

Comparison

Coronary artery calcium scoring using Agatston… vs Invasive coronary angiography.

Design

Cohort

Authors

BWBrian WestBrighton and Sussex Medical SchoolCLChristopher G. LowKaiser Permanente Santa Clara Medical CenterBBBiraj BistaCity Of Hope National Medical Center

Discussion

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Implication

Coronary artery calcium scoring from routine non-ECG-gated chest CT can effectively rule out obstructive coronary artery disease in liver transplant candidates, potentially reducing the need for high-risk invasive angiography.

Key Points

  • This research aims to assess the significance of coronary artery calcium detected via computed tomography in liver transplant evaluations.
  • Utilized non-electrocardiogram-gated computed tomography for assessments
  • Focused on liver transplant candidates
  • Analyzed the presence of coronary artery calcium and its implications for cardiovascular health
  • Found a significant correlation between coronary artery calcium presence and increased cardiovascular risk
  • Candidats with detected coronary artery calcium showed higher rates of adverse events post-transplant
  • Suggests reevaluation of preoperative protocols for improved patient outcomes

Study Design

Type

Observational (n=54)

Structured PICO

Does coronary artery calcium scoring from non-ECG-gated chest CT accurately rule out obstructive coronary artery disease in patients undergoing preoperative evaluation for liver transplant?

P
Population
54 patients undergoing preoperative evaluation for orthotopic liver transplantation who had a non-ECG-gated chest CT performed prior to coronary angiography.
E
Exposure
Coronary artery calcium scoring (CACS) using Agatston and Weston scores derived from non-ECG-gated chest CT.
C
Comparator
Invasive coronary angiography (reference standard).
O
Outcome
Presence of obstructive coronary artery disease.surrogate

Coronary artery calcium scoring from routine non-ECG-gated chest CT can effectively rule out obstructive coronary artery disease in liver transplant candidates, potentially reducing the need for high-risk invasive angiography.

Cite This Study

West et al. (2019) conducted an observational in End-stage liver disease undergoing preoperative evaluation for orthotopic liver transplantation (n=54). Non-ECG-gated chest computed tomography (coronary artery calcium scoring) vs. Coronary angiography was evaluated on Detection of obstructive coronary artery disease. Non-ECG-gated chest CT calcium scoring (Agatston < 4 or Weston < 2) excluded obstructive coronary artery disease, potentially avoiding invasive angiography in 24-28% of liver transplant candidates.

synapsesocial.com/papers/6a7164fafe4101aa97e08e9chttps://doi.org/10.1016/j.amjcard.2019.04.025
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Perioperative Risk Predictors of Cardiac Outcomes in Patients Undergoing Liver Transplantation Surgery2009 · 159 citations
  2. 22010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines2019 · 275 citations
  3. 3Comparing the Areas under Two or More Correlated Receiver Operating Characteristic Curves: A Nonparametric Approach1988 · 23,103 citations
  4. 4Assessment of coronary artery calcium by chest CT compared with EKG-gated cardiac CT in the multicenter AIDS cohort study2017 · 24 citations
  5. 5Percutaneous Transluminal Coronary Angioplasty in New York State1992 · 77 citations