Key result
MicroRNA-29 inhibition increases elastin levels across human vascular cells and bioengineered vessels.
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OBJECTIVE: The goal of this study was to determine whether antagonizing microRNA (miR)-29 enhances elastin (ELN) levels in cells and tissues lacking ELN. METHODS AND RESULTS: miR-29 mimics reduced ELN levels in fibroblasts and smooth muscle cells, whereas miR-29 inhibition increased ELN levels. Antagonism of miR-29 also increased ELN levels in cells from patients haploinsufficient for ELN and in bioengineered human vessels. CONCLUSION: miR-29 antagonism may promote increased ELN levels during conditions of ELN deficiencies.
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Zhang et al. (2011) studied Elastin haploinsufficiency / elastin deficiency. MicroRNA-29 (miR-29) inhibition / antagonism vs. miR-29 mimics / control was evaluated on Elastin (ELN) levels. MicroRNA-29 inhibition increased elastin levels in fibroblasts, smooth muscle cells, cells from elastin-haploinsufficient patients, and bioengineered human vessels.
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