Key result
Intravenous DEHSPM causes a profound blood pressure drop without altering heart rate, outperforming DENSPM ~5-fold.
Answers are grounded in this paper and cite their sources.
The impact of the antineoplastic polyamine analogues N1N14-diethylhomospermine (DEHSPM) and N1N11-diethylnorspermine (DENSPM) on the blood pressure and heart rate of normotensive and hypertensive rats are described. DEHSPM was administered to both normotensive and spontaneously hypertensive rats (SHR), while the DENSPM analogue was given only to the normotensive animals. The intravenous administration of DEHSPM at doses of 5 or 10 mg/kg resulted in a profound and long-lasting drop in the test animals' blood pressure, with no appreciable change in their heart rate. This was true for both the normotensive and the hypertensive animals. When administered at equivalent molar dosages, DENSPM was one fifth as effective as DEHSPM at reducing blood pressure. The impact of NG-nitro-L-arginine-methyl ester (L-NAME) and L-arginine on the analogues' activity is consistent with the involvement of nitric oxide.
No takes yet. Share an insight, caveat, or question.
Bergeron et al. (1995) studied Hypertension. N1N14-diethylhomospermine (DEHSPM) vs. N1N11-diethylnorspermine (DENSPM) was evaluated on Blood pressure and heart rate. Intravenous DEHSPM (5 or 10 mg/kg) caused a profound drop in blood pressure without changing heart rate, while DENSPM was one-fifth as effective.
Synapse has enriched 10 related papers. Consider them for comparative context: