Variation of Serum Lipid Levels During Diuretic Therapy of Hypertension

The change on serum total cholesterol and triglyseride in 78 patients of essential hypertension with treatment of diuretics and antihypertensives has been observed at same month or at least same season for 1-12 years (mean 5 years).1. In the patients treated with thiazide alone (1-2 Tab.) changes of total cholesterol and triglyceride levels in mean were from 205.8 to 213.8 and 11.6 to 119.6mg/dl respectively. These changes were not significant, however, elevation of total cholesterol over 30mg/dl and triglyceride over 50mg/dl was seen in several cases.2. There were no significant difference in the incidence of vascular diseases in group with thiazide alone, compared as group with α-Methyl-dopa and other antihypertensives. Uncontrolled hypertension and abnormal elevation of serum lipid were considered as the main factor of vascular diseases.3. Serum lipid should be measured repeatedly during long-term treatment with thiazide and other antihypertensives.