Why the study?
Does enprostil affect the gastroduodenal mucosa in healthy volunteers?
Population
103 healthy volunteers
Comparison
Enprostil 35 micrograms or 70 micrograms twice… vs Placebo twice daily (b.d.)
Design
RCT, randomized
Follow-up
28 days
Authors
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Enprostil warrants mucosal injury caution in at-risk patients; confirms adverse endoscopic effects via RCT in volunteers.
Does enprostil affect the gastroduodenal mucosa in healthy volunteers?
Oral enprostil causes dose-dependent gastric mucosal petechial hemorrhages in healthy volunteers, though these are likely clinically insignificant.
Lanza et al. (1990) studied this question.
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