Why the study?
Atrial fibrillation is common in end-stage renal disease, but differences in thromboinflammatory and oxidative stress biomarkers between ESRD patients with and without comorbid AF needed evaluation.
Do thrombo-inflammatory and oxidative stress biomarker levels differ in ESRD patients with versus without comorbid atrial fibrillation?
Do thrombo-inflammatory and oxidative stress biomarker levels differ in ESRD patients with versus without comorbid atrial fibrillation?
ESRD patients with comorbid AF exhibit distinct thrombo-inflammatory and oxidative stress biomarker profiles compared to those without AF, suggesting overlapping but distinct pathophysiological processes.
Supports further investigation of endothelial biomarkers in ESRD-AF; leaves open their clinical utility for risk stratification or therapy.
Background: Atrial fibrillation (AF) is a frequent comorbid condition in patients with end-stage renal disease (ESRD). AF presents thromboembolic risk, and loss of renal function in ESRD causes susceptibility to increasing oxidative stress level. Endothelial dysregulation may contribute to molecular and cellular imbalance involved in AF and be exacerbated with ESRD, illustrated by increased levels of circulating endothelial, inflammatory, and oxidative stress biomarkers. Methods: The study determines the differences between thrombo-inflammatory and oxidative stress biomarkers in ESRD patients with and without comorbid AF. Banked ESRD plasma samples were selected to identify patients with and without AF. Validated ELISA and appropriate statistical methods were used to profile the biomarkers and clinical correlates. Results: EPIC analysis reveals that the AF group has greater representation of male, black, and older patients than the non-AF group. Additionally, AF patients have higher comorbidity counts for disease states such as DVT, PE, and MI, and higher lab levels of liver enzymes, such as AST, ALP, ASP, and bilirubin. Initial analysis shows statistically significant difference in many thrombo-inflammatory and oxidative stress biomarker levels, such as thrombomodulin, in ESRD patients with and without AF, as well as moderate correlations between various biomarkers. Conclusion: ESRD patients with and without AF show high levels of thromboinflammatory and oxidative stress biomarkers. Moderate correlation between these biomarkers indicates relation between the two disease processes. The differences in correlation between various biomarkers for the two patient groups lends to understanding of the disease processes separately and concurrently. This study will be useful in assessing the pathophysiology of these disease states by evaluating biomarker levels in ESRD patients with or without AF. Funding: Other NIH Support - NIH T35 Research Training Program
No takes yet. Share an insight, caveat, or question.
Kaufmann et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: