Key result
Genome engineering tools accelerate genetic phenotyping and personalized therapeutics for cardiovascular disease.
Recent advances in the burgeoning field of genome engineering are accelerating the realization of personalized therapeutics for cardiovascular disease. In the postgenomic era, sequence-specific gene-editing tools enable the functional analysis of genetic alterations implicated in disease. In partnership with high-throughput model systems, efficient gene manipulation provides an increasingly powerful toolkit to study phenotypes associated with patient-specific genetic defects. Herein, this review emphasizes the latest developments in genome engineering and how applications within the field are transforming our understanding of personalized medicine with an emphasis on cardiovascular diseases.
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Campbell et al. (2013) conducted a review in Cardiovascular disease. Genome engineering / sequence-specific gene-editing tools was evaluated. Sequence-specific genome engineering tools and high-throughput models are accelerating the study of genetic phenotypes and personalized therapeutics for cardiovascular disease.
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