A transcultural mental health intervention: integrating Eastern, Western, and Arab psychological approaches in a mixed-methods feasibility intervention study

Background Culturally adapted mental health interventions may enhance engagement and effectiveness. This study developed a transcultural framework integrating Chinese,Western, and Saudi Arabian therapeutic principles. Objective: To evaluate the feasibility, acceptability, and preliminary outcomes of a transcultural mental health intervention in Chinese and Saudi Arabian clinical settings.Methods A 12-week mixed-methods feasibility study was conducted with 200 outpatients with mild-to-moderate anxiety or depression (100 per country). In each setting, 50 participants received the transcultural intervention and 50 received treatment-as-usual. Quantitative outcomes were assessed using validated Chinese and Arabic versions of the GAD-7 and PHQ-9. Qualitative data were collected through semi-structured interviews with 40 participants, including patients and clinicians, and analysed thematically.Results Both Chinese and Saudi participants in the intervention group showed significant reductions in anxiety (GAD-7: China 12.4→7.0; Saudi 13.2→6.8) and depression (PHQ-9: China 14.8→7.9; Saudi 15.7→8.1; p < 0.001). Qualitative findings highlighted strong cultural resonance, with cognitive-behavioural strategies integrated with mindfulness, Qi Gong, and Islamic-ethics-based family support enhancing engagement and perceived relevance. Clinicians reported improved trust, motivation, and session continuity.Conclusions The transcultural framework was feasible, acceptable, and culturally responsive, yielding meaningful symptom improvements. Integrating evidence-based and culturally grounded practices offers a promising approach for context-sensitive mental health interventions. Further controlled trials are warranted.