Physiologically relevant preclinical models and omic-wide approaches are essential to understand and mitigate kinase inhibitor-associated cardiotoxicity.
Physiologically relevant models with omics approaches may clarify kinase inhibitor cardiotoxicity mechanisms; leaves open rational drug design pending clinical validation.
models currently in use that are amenable for high-throughput screening as well as lower throughput models that are valuable for mechanistic insight. These physiologically relevant models, together with newer "omic"-wide approaches will help to increase our understanding of the mechanisms underlying kinase inhibitor-associated cardiotoxicity and enable rational design of kinase inhibitors in the future.
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Lamore et al. (2019) studied this question.
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