Quantitative Determination of Selectin-Carbohydrate Interactions

Q: What is the clinical evidence from this study?

Population: Inflammatory and immunological leukocyte adhesion. Intervention: Selectin-carbohydrate interactions (E-, P-, and L-selectin).

Q: What does this research mean for the field?

The three selectin family members (E-, P-, and L-selectin) are transmembrane glycoproteins that mediate leukocyte adhesion to the vessel wall during inflammation. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

R M Nelson; Alejandro Aruffo; Sylvia Dolich; O Cecconi; Gianna Mannori; M P Bevilacqua

doi:10.1101/sqb.1992.057.01.032

January 1, 1992Cold Spring Harbor Symposia on Quantitative Biology

Quantitative Determination of Selectin-Carbohydrate Interactions

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Key Points

Characterize and quantify the molecular interactions between selectin family cell adhesion molecules and their carbohydrate ligands during inflammatory responses.
Examined cell adhesion dynamics using in vitro cultured endothelial cell monolayers.
Assayed cells transfected with cDNA encoding E-selectin following stimulation with bacterial endotoxin or inflammatory cytokines, including IL-1 and TNF.
E-selectin expression is induced on endothelial surfaces following activation by inflammatory cytokines (IL-1, TNF) and bacterial endotoxin.
Selectins mediate leukocyte tethering and adhesion via conserved amino-terminal lectin-like domains interacting with carbohydrate determinants.

PICO

P

Population

Inflammatory and immunological leukocyte adhesion

I

Intervention / Comparator

Selectin-carbohydrate interactions (E-, P-, and L-selectin)

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Implication

Reveals mechanisms of selectin-carbohydrate adhesion during vascular inflammation, highlighting molecular targets for anti-inflammatory therapies.

Abstract

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Cite This Study

Nelson et al. (1992) studied Inflammatory and immunological leukocyte adhesion. Selectin-carbohydrate interactions (E-, P-, and L-selectin) was evaluated.

synapsesocial.com/papers/6a7176adc2d7c30908270f31 https://doi.org/10.1101/sqb.1992.057.01.032

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Quantitative Determination of Selectin-Carbohydrate Interactions

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PICO

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Implication

Abstract

Discussion

Cite This Study

Quantitative Determination of Selectin-Carbohydrate Interactions

Key Points

PICO

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Implication

Abstract

Discussion

Cite This Study

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