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October 1, 1981Journal of Medicinal Chemistry

N-N-S* Tridentate ligand system as potential antitumor agents

Ippolito Antonini Francesco Claudi Gloria Cristalli Palmarisa Franchetti Mario Grifantini Sante Martelli

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Abstract

Compounds containing an N*-N*-S* tridentate ligand were synthesized and tested for antitumor activity against P-388 lymphocytic leukemia in mice. Of these, only 2,2'-bipyridyl-6-carbothioamide (1a) showed antitumor activity at relatively high dosage levels. Compound 1a was also evaluated against L-1210 and S180 cells in culture and found to have significant activity.

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Antonini et al. (1981) studied this question.

synapsesocial.com/papers/6a7176caf44fa9f079df4457 https://doi.org/10.1021/jm00142a012

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