Antigenic Diversity of Mammalian Papillomaviruses

Ontogenesis of Trichothecium roseum during biosynthesis of trichothecin was studied during submerged cultivation on maize and synthetic media. Growth of the fungus is polycyclic; several generations of the submerged mycelium develop from the submerged conidia on the maize medium, and from the submerged conidia, chlamydospores and budding mycelium on the synthetic medium. Differentiation of the mycelium favours biosynthesis of the antibiotic. The nuclei in the cells of the submerged mycelium differ by their number, dimensions, and shape (round and elongated, polyploid). Several nuclei are found in the cells of the submerged mycelium more often during growth on the synthetic medium; this phenomenon is related to the reproductive cells -- submerged conidia and chlamydospores.