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Investigations were performed on the effect of various doses of sheep erythrocyte antigen on spleen germinal center changes. These changes were correlated with the production of specific serum antibody during the first 30 days after primary antigen stimulation. The results indicate a dose-response relationship between antigen dose and germinal center changes. A correlation was observed between the germinal center changes and specific serum antibody production.
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Hanna et al. (1966) studied this question.
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