Key result
Both low and high total cholesterol show a U-shaped link to higher cardiovascular mortality.
Cohort (n=12,740)
Yes
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This study was conducted to evaluate the association of single serum total cholesterol (TC) measurement with cardiovascular diseases (CVD) deaths in Korean adults. The study subjects were taken from the multi-site collaborative dynamic prospective cohort for epidemiologic investigation on cancer risk in residents nearby nuclear power plants in Korea. A total of 12,740 adults aged 40 to 69 yr who underwent a mass screening examination were followed up from 1993 to 2008. Occurring CVD deaths were confirmed by the death certificates in the National Statistical Office, Korea. Groups with the lowest group having TC < 160 mg/dL as well as the highest group having >= 240 mg/dL were associated with higher CVD mortality in Cox proportional hazards analysis adjusting for age, sex, smoking and drinking status, body mass index, level of blood pressure, triglyceride and high density lipoprotein cholesterol. The distribution of adjusted hazard ratios showed the U-shaped curve. Based on the results of this study, caution should be taken in prescribing statins for primary prevention among people at low cardiovascular risk in Korean adults.
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Bae et al. (2011) conducted a cohort in Cardiovascular diseases mortality (n=12,740). Single serum total cholesterol (TC) measurement (<160 mg/dL or >=240 mg/dL) vs. Intermediate total cholesterol (160-239 mg/dL) was evaluated on Cardiovascular disease (CVD) mortality. Serum total cholesterol <160 mg/dL and >=240 mg/dL were both associated with higher cardiovascular disease mortality in a U-shaped adjusted hazard ratio distribution among 12,740 Korean adults.
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