Antimonial antileishmanial drugs may owe their activity to the formation of a 1:1 complex between Sb and trypanothione—a glutathione/spermidine conjugate that is essential for the growth and survival of trypanosomatid protozoan parasites such as Leishmania. On the basis of the MS and 2D NMR data of the complex, a structure is proposed in which a SbIII ion is bound to the S atoms of cysteine residues, and the coordination sphere of Sb is completed by the oxygen atom of a water molecule (OW; see picture).
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Yan et al. (2000) studied this question.
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