Urinary Output of Adrenaline, Noradrenaline, and 3-Methoxy-4-Hydroxymandelic Acid Following Centrifugation and Anticipation of Centrifugation *

It has been shown that various forms of stress, i.e., thermal burn (1), muscular exercise (2), centrifugation (3-5), trauma (6) and so forth activate the sympatho-adrenal system and that this activation is manifested by an increase in the urinary output of adrenaline and noradrenaline. Furthermore, it has been demonstrated in the normal human that 3-methoxy-4-hydroxymandelic acid is one of the principal metabolic products of both adrenaline and noradrenaline (7-10). Hitherto, there have been no stress experiments correlating the urinary output of adrenaline and noradrenaline with that of 3-methoxy-4-hydroxymandelic acid. The experiments herein described not only demonstrate such a correlation but also show the effect of centrifugation and anticipation of centrifugation upon the urinary output of adrenaline, noradrenaline, and 3-methoxy-4-hydroxymandelic acid.