This case report highlights the potential for high-dose intravenous methylprednisolone to induce nocturnal sinus bradycardia.
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IV methylprednisolone may induce nocturnal sinus bradycardia in MS; this case leaves open whether monitoring is warranted.
Article AbstractBecause this piece does not have an abstract, we have provided for your benefit the first 3 sentences of the full text.To the Editor: Some cases of sinus bradycardia caused by intravenous methylprednisolone have been documented, but to the best of our knowledge, however, ours is the first report of nocturnal sinus bradycardia caused by intravenous methylprednisolone.Case report. Ms A is a 54-year-old white woman with a 10-year history of relapsing remitting multiple sclerosis (MS), vitamin D deficiency, gastric reflux, and hyperlipidemia who was admitted for a reexacerbation of her MS. She was started on intravenous methylprednisolone 1 g in 250 mL of 0.9% normal saline administered daily over a 3-hour period for 5 days.
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Osuagwu et al. (2016) studied this question.
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