Why the study?
Does the presence of hypertension or diabetes mellitus increase oxidative stress in an elderly population?
Does the presence of hypertension or diabetes mellitus increase oxidative stress in an elderly population?
In an elderly population, hypertension is a major driver of increased oxidative stress, whereas diabetes mellitus alone does not appear to have a significant effect.
Small observational data leave clinical implications uncertain; extends limited evidence on oxidative stress in DM/HT but remains hypothesis-generating.
Background Mexico City has the highest aging rate in the country, as well as a high prevalence of diabetes mellitus (DM) and arterial hypertension (HT). All three on their own, are known to increase oxidative stress (OE). Methods Final groups included 18 patients without DM or HT (control group), 12 with DM, 23 with HT, and 18 with DM and HT. The EO was measured by the quantification of reactive oxygen species (ROS), and by determination of lipid peroxidation. Results HAS patients showed increased ROS levels as did men with HAS compared with the respective DM and HT groups. Also, women of the control group showed higher levels of ROS compared with men. HT in an aged population turned out to be the most influential factor for oxidative stress increase while DM had no effect whatsoever.
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Rodríguez-Castañenda et al. (2018) studied this question.
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