A Substructure Approach toward Polymeric Receptors Targeting Dihydrofolate Reductase Inhibitors. 2. Molecularly Imprinted Polymers against Z-l-Glutamic Acid Showing Affinity for Larger Molecules

The preparation of a molecularly imprinted polymer against N-Z-L-glutamic acid using a novel bis-urea functional monomer is described. The polymer exhibits affinity for the template over N-Z-protected aspartic acid and glycine and, further, is capable of binding larger molecules, e.g., the anti-cancer drug methotrexate, containing the glutamate substructure.