1 The interaction between phenylephrine and debrisoquine was studied using normal and hypertensive human volunteers, measuring blood pressure, pulse rate and pupil diameter. Single doses of phenylephrine were given before, during and after a short course of debrisoquine treatment. 2 The circulatory effects of phenylephrine are potentiated by debrisoquine; in a few subjects this potentiation was marked and a potential hazard. 3 Limited deductions could be made about the effects of debrisoquine on baroceptor responses and adrenergic mechanisms.
No takes yet. Share an insight, caveat, or question.
ALLUM et al. (1974) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: