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A terahertz spectroscopic imaging system was fabricated for the detection of two-dimensional molecular distributions in pharmaceutical tablets based on absorption peaks of intermolecular or intramolecular hydrogen bonds in crystals. The terahertz imaging system consists of a terahertz time-domain spectrometer and a three-dimension translational stage. Using the system, we obtained frequency-dependent terahertz images of famotidine polymorphic forms A and B. An offset subtraction process is useful for detecting the distribution in an inhomogeneous tablet containing a mixture of the two forms. The terahertz imaging technique is a valuable tool for the analysis of polymorphic forms of crystal in inhomogeneous pharmaceutical tablets.
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Ajito et al. (2011) studied this question.
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