Key result
Anticoagulation in PNH with hepatic venous thrombosis triggers HIT, splenic infarction, and rupture requiring splenectomy.
Case Report (n=1)
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We describe a patient with paroxysmal nocturnal hemoglobinuria (PNH) and no previous history of thrombosis who presented with hepatic venous thromboses and subsequently developed splenic infarction and rupture requiring splenectomy while on anticoagulation therapy for the hepatic thromboses. The patient's anticoagulation was complicated by heparin-induced thrombocytopenia (HIT) highlighting the unique management challenge presented by PNH in combination with HIT.
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Magnan et al. (2009) conducted a case report in Paroxysmal nocturnal hemoglobinuria (PNH) complicated by hepatic venous thromboses and heparin-induced thrombocytopenia (HIT) (n=1). Anticoagulation therapy and splenectomy was evaluated on Splenic infarction and subsequent splenic rupture requiring splenectomy. Anticoagulation therapy in 1 patient with PNH and hepatic venous thromboses was complicated by HIT, splenic infarction, and rupture requiring splenectomy.
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