Why the study?
Bone morphogenetic protein-4 regulates inflammation in arterial and organ diseases, but its relationship with perioperative inflammation remains unclear.
Does flurbiprofen reduce circulating BMP4 and inflammatory cytokines in patients undergoing lobectomy?
Does flurbiprofen reduce circulating BMP4 and inflammatory cytokines in patients undergoing lobectomy?
Circulating BMP4 is elevated during thoracic surgery and correlates with inflammatory cytokines, an effect that can be attenuated by intraoperative flurbiprofen.
Authors
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Flurbiprofen may blunt perioperative inflammation; extends BMP4's pro-inflammatory role from vascular disease to acute surgical settings.
Zhao et al. (2021) studied this question.