Symptoms and signs of bronchial asthma, associated with cor pulmonale, are rare clinical findings in infants and children. Three cases are presented which suggest a relationship between the two entities. Two of the three cases did not present any evidence of atopy. Although studies of cardiopulmonary functions should be done in all children suffering from "bronchial asthma," it is essential that the cardiac status be evaluated whenever a patient with asthma is responding poorly to treatment or evidence of decreased pulmonary function is found. It is hoped that this presentation will alert physicians to cor pulmonale as a complication of asthma.
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Griffin et al. (1959) studied this question.