Key result
Once-daily propranolol achieves blood pressure control similar to four-times-daily dosing in hypertension.
Twenty patients with essential hypertension, who were receiving a diuretic plus propranolol qid, were instructed to take their entire daily requirement of propranolol as a single morning dose. Blood pressure was measured in standing and supine positions at the end of a dosing interval. Patients were questioned about the occurrence of specific propranolol side effects during each of four bi-weekly evaluations. Mean blood pressure on once-daily propranolol did not differ significantly from that observed on propranolol qid. Daily doses of propranolol ranged from 80-320 mg. Side effects were infrequent and mild. We conclude that propranolol may be administered as a single daily dose to patients with hypertension whose blood pressure already has been controlled on a qid regimen.
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Lopez et al. (1984) studied Essential hypertension (n=20). Once-daily propranolol vs. Propranolol four times daily (qid) was evaluated on Mean standing and supine blood pressure at the end of a dosing interval. Once-daily propranolol (80-320 mg/day) produced no significant difference in mean blood pressure compared with four-times-daily dosing in 20 patients with controlled hypertension.
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