Rare central nervous system co-infection with Scedosporium apiospermum and Acanthamoeba species: A case report.

Both Acanthamoeba species and Scedosporium species cause central nervous system infection. They are associated with high mortality and lack clear guidelines with regards to treatment. A co-infection with both organisms, therefore, becomes difficult to diagnose and treat. This case report highlights the presentation of such a co-infection. The importance of looking for an alternate diagnosis in a clinically deteriorating patient with complicated meningoencephalitis using microbiological aids, surgery for the diagnosis and source control of infection along with the challenges associated with managing such a patient are described.