Population
Calcium-saturated troponin-tropomyosin actin filaments and myosin subfragment 1 (S-1)
Comparison
Addition of 5.0 mM magnesium 5'-adenylyl… vs Nucleotide-free acto-S-1 complexes and…
Design
Preclinical
Authors
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No immediate clinical implications; leaves open whether MgAMPPNP potentiation alters cardiac thin-filament regulation in vivo.
The study demonstrates that a potentiated state of the tropomyosin actin filament, characterized by increased Vmax of acto-S-1 ATPase activity and altered binding constants, can be produced by the cooperative action of acto-S-1 or acto-S-1-AMPPNP complexes.
Murray et al. (1982) studied this question.
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