Why the study?
Does carotid endarterectomy improve safety and efficacy in asymptomatic patients?
Does carotid endarterectomy improve safety and efficacy in asymptomatic patients?
Quantitative synthesis suggests that the use of a surgical shunt could further improve outcomes of carotid endarterectomy in asymptomatic patients.
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May support shunt use in asymptomatic CEA to reduce perioperative risk; extends meta-analytic evidence on technical adjuncts.
Carotid endarterectomy (CE) surgery for asymptomatic patients remains controversial despite hundreds of published studies and recent randomized trials. Safety and efficacy are assessed using a quantitative synthesis method derived from meta-analysis and a "critical multiplist" inference approach. In addition, multivariate analyses reveal that use of a surgical shunt could further improve CE outcomes. Methods are examined for both their "confirmatory" and "exploratory" value.
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Langenbrunner et al. (1993) studied this question.
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