Rat plasma metabolomics in blood stasis model based on ultra performance liquid chromatography-quadrupole-time-of-flight mass spectrometry

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6-trimethyl-L-lysine, cytosine, and acetylcarnitine, while 25 metabolites were reduced, including indoleacrylic acid, and lysoPC(14:0). These metabolites were mainly related to metabolic pathways, including lipid metabolism, galactose metabolism, linoleic acid metabolism, biosynthesis of unsaturated fatty acids, glycolysis, and arachidonic acid metabolism. In conclusion, these results indicated that metabolites could be used as important biomarkers for blood stasis syndrome, and could help in revealing the mechanism of blood stasis disease and provide a reference network to determine the disease development stage and appropriate follow-up treatment. Studying altered metabolites in blood stasis model rats can provide insights useful for the diagnosis of blood stasis in the clinic and for the development of drug therapies.