Key result
Modular genomics enables biomarker development for monitoring disease activity in SLE and lupus nephritis.
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Monitoring disease activity in a complex, heterogeneous disease such as lupus is difficult. Both over- and undertreatment lead to damage. Current standard of care serologies are unreliable. Better measures of disease activity are necessary as we move into the era of precision medicine. We show here the use of a data-driven, modular approach to genomic biomarker development within lupus-specifically lupus nephritis.
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Zollars et al. (2016) conducted a review in Systemic lupus erythematosus (specifically lupus nephritis). Modular genomics technique for biomarker development was evaluated on Monitoring of disease activity in lupus nephritis. A data-driven, modular genomics approach can be utilized to develop genomic biomarkers for monitoring disease activity in systemic lupus erythematosus and lupus nephritis.
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