Answers are grounded in this paper and cite their sources.
It is generally believed that most tumor antigens are passively released from either health or dying tumor cells as intact soluble antigens, peptide fragments complexed with heat shock proteins (HSPs), or packaged in secretary vesicles in the form of microparticles or exosomes. The passive release of tumor antigens is generally non-inflammatory and non-immunogenic; however, results from others and our laboratories suggest that autophagy is critically involved in immunogenic cell death.
No takes yet. Share an insight, caveat, or question.
Yi et al. (2012) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: